A growth cone is a part of a neuron considered as a hub for axon growth, motility and guidance functions. Growth cones are thought to play a critical role during development of neurons. Growth cones also play a significant role in adult regeneration. Here, we present a dataset on the lipid and protein profiling of the growth cone-enriched fractions derived from C57BL/6J mice forebrains of developmental stage: E18, P0, P3, P6, and P9. For comparison, we analyzed non-growth cone membranes from the same samples. Lipid data is available at the Metabolomics Workbench [http://www.metabolomicsworkbench.org (Project ID: PR000746)]. Protein data is available at Proteomics Identifications (PRIDE) partner repository (PRIDE identifier PXD012134).
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http://dx.doi.org/10.1016/j.dib.2019.103865 | DOI Listing |
Invest Ophthalmol Vis Sci
May 2021
Biosciences Institute, Newcastle University, Newcastle, United Kingdom.
Purpose: Retinoblastoma (Rb) is a malignant neoplasm arising during retinal development from mutations in the RB1 gene. Loss or inactivation of both copies of RB1 results in initiation of retinoblastoma tumors; however, additional genetic changes are needed for the continued growth and spread of the tumor. Ex vivo research has shown that in humans, retinoblastoma may initiate from RB1-depleted cone precursors.
View Article and Find Full Text PDFData Brief
June 2019
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL 33136, USA.
A growth cone is a part of a neuron considered as a hub for axon growth, motility and guidance functions. Growth cones are thought to play a critical role during development of neurons. Growth cones also play a significant role in adult regeneration.
View Article and Find Full Text PDFStem Cell Reports
December 2017
Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK; NIHR Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:
Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retinal degeneration. Transplantation of stem cell-derived L/M-opsin cones, which form 90% of the human cone population, could provide a feasible therapy to restore vision. However, transcriptomic similarities between fetal and stem cell-derived cones remain to be defined, in addition to development of cone cell purification strategies.
View Article and Find Full Text PDFGenome Biol
September 2015
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO, USA.
Background: Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity. Five well-characterized mouse models carrying different Crx mutations show a wide range of disease phenotypes. To determine if the phenotype variability correlates with distinct changes in CRX target gene expression, we perform RNA-seq analyses on three of these models and compare the results with published data.
View Article and Find Full Text PDFNovartis Found Symp
March 2004
Laboratoire de Physiopathologie Cellulaire et Moléculaire de la Rétine, Université Pierre et Marie Curie, Inserm u592, Hôpital Saint-Antoine, Bâtiment Kourilsky, 6ème étage, 184 rue du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France.
During the last decade, numerous research reports have considerably improved our knowledge of the pathophysiology of retinal degenerations. Three non-mutually exclusive general areas dealing with therapeutic approaches have been proposed: gene therapy, pharmacology and retinal transplantations. The observation that cone photoreceptors, even those seemingly unaffected by any described anomaly, die secondarily to rod disappearance related to mutations expressed specifically in the latter, led us to study the interactions between these two photoreceptor populations to search for possible causal links between rod degeneration and cone death.
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