AI Article Synopsis
- The study focused on analyzing the essential oil's chemical makeup, including key components like β-Pinene and α-Pinene, with no detected acute toxicity at high doses.
- The essential oil showed significant pain relief (65.84% reduction in writhing) through an opioid-like mechanism, comparable to morphine.
- It also exhibited strong antimicrobial properties against both Gram-positive and Gram-negative bacteria and fungi, along with noteworthy antioxidant activity, indicating promising pharmaceutical potential.
Article Abstract
This work aimed to investigate the chemical composition, antimicrobial, antinociceptive, acute toxicity and antioxidant activity of the essential oil of (EOAm). The essential oil presented as the major constituents β-Pinene (56.99%), α-Pinene (16.57%), Germacrene D (4.67%), Bicyclogermacrene (4.66%), (E)-Caryophyllene (3.76%) and Limonene (1.71%). It was verified that the essential oil did not show acute toxicity in the maximum dose of 5,000 mg/kg. In the evaluation of the antinociceptive activity it was verified that the essential oil reduced in 65.84% the number of writhing in the mice, reducing the pain in 59.17%, and the mechanism of action in pain reduction was opioid, similar to morphine. The essential oil also presented significant antimicrobial against Gram positive and Gram-negative bacteria and fungi, and the antioxidant activity was relevant. Therefore, these results demonstrate the great potential for the future development of pharmaceutical products with the essential oil of .[Figure: see text].
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| http://dx.doi.org/10.1080/14786419.2019.1602832 | DOI Listing |
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