It is well known that wood structural members can stand a relatively heavy load in the short term but will gradually get weaker if the load is applied for a longer period. This phenomenon is caused by the damage accumulation effect in wood and should be appropriately considered during the design of timber structures. Although various formulation methods (also known as classical models) have been proposed to evaluate the damage accumulation effect in wood, the calibration of model parameters is very time-consuming. Our work proposes a novel method to deal with the damage accumulation effect in wood that involves the application of machine learning algorithms. The proposed algorithm considers a multi-objective optimization process with a combination of goodness-of-fit and complexity. Long-term experimental data of typical wood species are used for developing the machine learning based damage accumulation model. Compared with existing pre-formulated models, our model managed to reduce the complexity of the model structure and give sufficiently accurate and unbiased predictions. This study aims to provide a novel tool for evaluating the damage accumulation in wood structural members, and the proposed model can further support the life-cycle performance assessment of timber structures under long-term service scenarios.
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http://dx.doi.org/10.3390/ma12081243 | DOI Listing |
FASEB J
March 2025
State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, P. R. China.
Copper exposure poses potential detrimental effects on both public and ecosystem health. Spermidine, an antioxidant, has shown promise in reducing oxidative stress and inflammation within the liver. However, its specific role in mitigating copper-induced hepatic cuproptosis and disturbances in copper metabolism remains unexplored.
View Article and Find Full Text PDFInt J Cosmet Sci
March 2025
Hangzhou Shiguang Xinya Biotechnology Co., Ltd., Hangzhou, China.
Objective: The study investigated effects of peony callus extracts (PCE) on the protective efficacy against Ultraviolet B (UVB)-induced photoageing, using in vitro and in vivo studies. The research focused on PCE's ability to protect against inflammatory factors, DNA damage and accumulation of senescent cells, along with the evaluation of the extract's potential anti-photoageing benefits to skin.
Methods: Human keratinocyte cell line (HaCaT cells), mast cells and fibroblasts were used to evaluate the role of PCE in anti-photoageing.
Nutrients
March 2025
College of Resources, Environment, and Chemistry, Chuxiong Normal University, Chuxiong 675000, China.
Background: Benth is commonly utilized in China to take advantage of its purported health benefits.
Methods: Here, the chemical composition, nutritional value, and bioactivity of Benth extract (CGE) are characterized, and the mechanisms through which it functions were explored.
Results: CGE was found to exhibit a favorable nutritional and biosafety profile, especially due to its high amino acid and mineral contents.
Nutrients
February 2025
Postgraduate Program in Neuroscience and Cell Biology, Federal University of Pará/UFPA, Rua Augusto Corrêa 01, Bairro Guamá, Belém 66075-110, PA, Brazil.
Chronic treatment with dapsone (DDS) has been linked to adverse reactions involving all organ systems, such as dapsone hypersensitivity syndrome, methemoglobinemia and hemolytic anemia, besides neuroinflammation and neurodegeneration due to iron accumulation and oxidative stress. These effects probably occur due to the presence of its toxic metabolite DDS-NOH, which can generate reactive oxygen species (ROS) and iron overload. In this sense, antioxidant compounds with chelating properties, such as alpha-lipoic acid (ALA), may be an interesting adjuvant therapy strategy in treating or preventing these effects.
View Article and Find Full Text PDFNutrients
February 2025
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Advanced glycation end products (AGEs) represent a class of toxic and irreversible compounds formed through non-enzymatic reactions between proteins or lipids and carbonyl compounds. AGEs can arise endogenously under normal metabolic conditions and in pathological states such as diabetes, kidney disease, and inflammatory disorders. Additionally, they can be obtained exogenously through dietary intake, particularly from foods high in fat or sugar, as well as grilled and processed items.
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