Crystalline primycin was found to be very active in broth dilution assay against Staphylococcus aureus (50 strains), Staphylococcus epidermidis (77 strains), Streptococcus faecalis (76 strains) and one strain of Listeria monocytogenes with minimal inhibitory concentrations (MIC) of 0.12-0.5 microgram/ml. The activity was influenced by the pH of the liquid medium with greater activity (lower MICs) at pH 8 against the majority of strains, than at pH 6 or 7.3. In disc agar diffusion assay Bacillus subtilis ATCC 6633 proved more sensitive than staphylococcus strains.
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