AI Article Synopsis
- Respiratory syncytial virus (RSV) can cause serious lower respiratory infections, especially in children and the elderly, leading to prolonged illness and increased hospitalization.
- The study employs a simplified model using ordinary differential equations to explore how the transfer of the virus between upper and lower respiratory tracts affects the severity and duration of infections.
- The findings suggest that different rates of viral diffusion and advection contribute to long-lasting infections in the lower respiratory tract, providing insights into why severe LRI cases occur in affected populations.
Article Abstract
Respiratory syncytial virus can lead to serious lower respiratory infection (LRI), particularly in children and the elderly. LRI can cause longer infections, lingering respiratory problems, and higher incidence of hospitalization. In this paper, we use a simplified ordinary differential equation model of viral dynamics to study the role of transport mechanisms in the occurrence of LRI. Our model uses two compartments to simulate the upper respiratory tract and the lower respiratory tract (LRT) and assumes two distinct types of viral transfer between the two compartments: diffusion and advection. We find that a range of diffusion and advection values lead to long-lasting infections in the LRT, elucidating a possible mechanism for the severe LRI infections observed in humans.
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| http://dx.doi.org/10.1007/s00285-019-01364-1 | DOI Listing |
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