Palladium catalyzed chemo- and site-selective C-H acetoxylation and hydroxylation of oxobenzoxazine derivatives.

An efficient protocol for the introduction of acetoxy and hydroxy functionalities on unactivated aryl sp2 carbons of oxobenzoxazine derivatives via an ortho-C-H activation reaction using a palladium catalyst has been developed for the first time. Interestingly, this intermolecular C-H functionalization reaction takes place in a facile and simple manner with high chemo- and site selectivity.