Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients.

Purpose: To analyze and compare corneal structural and biomechanical properties, characterized by corneal hysteresis (CH) and resistance factor (CRF), between patients with and without type 2 diabetes mellitus (DM), and determine the main ocular variables that influence them.

Methods: Sixty diabetic and 48 age- and sex-matched non-DM patients were enrolled in this cross-sectional study. The DM group was analyzed according to DM duration (
Results: There were no statistically significant differences in the CH and the CRF between DM and non-DM groups (=0.637 and =0.439, respectively). Also, there was no statistical difference between groups for the CCT, IOPcc, or IOP-GAT. Multivariate linear regression analysis showed that CH was positively associated with CCT ( < 0.001) and negatively associated with IOPcc ( < 0.001), while CRF was positively associated with CCT ( < 0.001) and IOPcc (=0.014).

Conclusion: The CCT and IOPcc were found to be the main parameters that affect corneal biomechanical properties both in diabetics and controls. In this study, there was no significant effect of DM type 2 on corneal biomechanics.