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http://dx.doi.org/10.1016/j.ad.2018.05.015 | DOI Listing |
Cureus
December 2024
Dermatology, Temple University Hospital, Philadelphia, USA.
Leprosy is an uncommon chronic mycobacterial infection in the United States caused by . There are two major forms of the infection, lepromatous leprosy and tuberculoid leprosy, with borderline forms of each. Leprosy is even more uncommon in the Northeastern United States and can present with various symptoms and skin findings, including erythematous or hypopigmented patches or plaques with accompanying hypoesthesia or anesthesia, anhidrosis, or alopecia.
View Article and Find Full Text PDFBMC Cancer
December 2023
Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, No. 127 Dongming Road, Jinshui District, Zhengzhou City, 450008, Henan Province, China.
Background: Novel ADC drugs provide a new therapeutic strategy for gastric cancer.The present study aimed to analyze the clinical efficacy and drug toxicities of disitamab vedotin (RC48) plus immune checkpoint inhibitors(ICIs) and RC48 as third-line therapies and beyond for advanced and metastatic gastric cancer patients.
Methods: This was an observational multicenter real-world study.
Cancer Med
December 2023
Department of Oncology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Surg Neurol Int
December 2022
Department of Neurosurgery, Helen Joseph Hospital, Johannesburg, South Africa.
Background: Keyhole neurosurgery is the notion of safely removing brain and skull base lesions through smaller and more precise openings that lessen collateral damage to the surrounding scalp, brain, blood vessels, and nerves. The traditional frontal and pterional approaches require large craniotomies and this predisposes patients to significant and avoidable morbidity. With the growing expectation for minimally invasive surgery, we present our experience with the supraorbital keyhole craniotomy for surgical lesions in the anterior cranial fossa and parasellar regions.
View Article and Find Full Text PDFClin Cancer Res
January 2021
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, China.
Purpose: To evaluate the efficacy and safety of RC48-ADC, a novel humanized anti-HER2 antibody conjugated with monomethyl auristatin E, in patients with HER2 locally advanced or metastatic urothelial carcinoma (mUC) refractory to standard therapies.
Patients And Methods: This was a phase II, open-label, multicenter, single-arm study of patients with HER2 (IHC status 3+ or 2+) locally advanced or mUC who previously failed at least one line of systemic chemotherapy. The primary endpoint was the objective response rate (ORR) assessed by a blinded independent review committee (BIRC).
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