Multipotent Mesenchymal Stromal Cells for Pulmonary Fibrosis?

Am J Med Sci

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Published: May 2019

AI Article Synopsis

  • Patients with terminal conditions and their healthcare providers are increasingly turning to alternative treatments like stem cell therapy due to desperation for viable options.
  • The rise of unapproved stem cell therapies globally is fueled by the urgent need for effective treatments, despite the lack of scientific backing.
  • While initial trials show promise, significant challenges remain, from fundamental research gaps to the complexities of clinical implementation, preventing stem cell therapies from being ready for widespread use.

Article Abstract

With the combination of ideologic beliefs and the will to survive, fraught patients and determined clinicians seek alternative therapies for treatment of terminal conditions, such as idiopathic pulmonary fibrosis. Unfortunately, the need for treatment has supported the growth of unapproved stem cell therapy over the years spanning across many countries. The reality, however, is that the science behind this therapy is lagging. While there have been promising results from phase I trials, there remain multiple reasons that "stem cells" are not ready for clinical application, starting from a gap in understanding at the bench research level, all the way to optimal clinical application in order to provide effective therapy.

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Source
http://dx.doi.org/10.1016/j.amjms.2019.02.007DOI Listing

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