Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/01443615.2019.1572078 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-grade B-cell lymphoma not otherwise specified, with diffuse large B-cell lymphoma gene expression signatures: Genomic analysis and potential therapeutics.
Am J Hematol
January 2025
Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Article Synopsis
- High-grade B-cell lymphoma not otherwise specified (HGBCL, NOS) shares similarities with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL), which complicates its diagnosis and treatment.
- A study on a cohort of 55 patients revealed that about 60% of HGBCL, NOS cases don't express the BL gene signature and instead display characteristics aligned with DLBCL, while showing significant genetic diversity and changes in critical regulatory genes.
- Pediatric HGBCL, NOS cases exhibited gene expressions typical of GCB-DLBCL and also showed key mutations seen in pediatric BL; the research highlighted PIM1 mutations in adults as a potential target for new therapies.
Quantification of micropapillary component on transurethral resection is associated with likelihood of occult lymph node metastasis at radical cystectomy.
Urol Oncol
October 2024
Department of Anatomic Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
Article Synopsis
- Micropapillary variant urothelial carcinoma (MPUC) is linked to higher treatment failure risks and occult lymph node metastasis, impacting outcomes after radical cystectomy (RC).
- The study evaluated 67 patients with MPUC to see how the percentage of MPUC in tissue samples affects lymph node positivity and patient survival following treatment.
- Results indicated that a higher percentage of MPUC (≥30%) and advanced clinical stage (≥T2) were significant predictors of lymph node metastasis at RC, with patients having cT1 disease showing the lowest metastasis rates.
Prevalence, Management, and Outcomes of Atrial Fibrillation in Paediatric Patients: Insights from a Tertiary Cardiology Centre.
Medicina (Kaunas)
September 2024
Pediatric Cardiology Department, Reference Center for Congenital Heart Diseases, Hospital de Santa Marta, Unidade Local de Saúde São José EPE, 1150-199 Lisbon, Portugal.
Atrial fibrillation (AF) is increasingly recognised in paediatric patients, presenting unique challenges in management due to its association with various underlying heart conditions. This study aimed to evaluate the prevalence, management strategies, and outcomes of AF in this population. : A retrospective analysis was conducted at a tertiary paediatric cardiology centre, including patients aged ≤18 years diagnosed with AF between January 2015 and December 2023.
View Article and Find Full Text PDFInvestigating the antioxidant and anticancer potential of Daucus spp. extracts against human prostate cancer cell line C4-2, and lung cancer cell line A549.
J Ethnopharmacol
January 2025
Transcriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, 190025, J&K, India. Electronic address:
Article Synopsis
- The study analyzed 297 carrot germplasm lines, focusing on 52 cultivars to assess their health benefits and address issues with the availability and cost of nutraceuticals.
- Using DNA barcoding and ITS sequence analysis, researchers identified genetic diversity among carrot cultivars, classifying six distinct Daucus spp. genotypes.
- Antioxidant activities and potential anti-cancer effects were tested, highlighting specific carrot genotypes that showed promise for developing functional foods and health supplements aimed at cancer treatment and prevention.
Lone-Star retractor perineal exposure method for laparoscopic abdominal perineal resection of rectal cancer.
World J Gastrointest Surg
August 2024
Department of General Surgery, Anqing Municipal Hospital, Anqing 246000, Anhui Province, China.
Background: The abdominal perineal resection (APR), historically referred to as Mile's procedure, stands as a time-honored surgical intervention for rectal cancer management. Advancements in surgical techniques and the advent of neoadjuvant therapies have significantly improved the rate of sphincter preservation among patients afflicted with rectal cancer, including those with ultralow rectal cancer. Despite these improvements, APR maintains its irreplaceable role in the clinical landscape, particularly for cases involving low rectal cancer with encroachment on the external anal sphincter or levator ani muscles.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!