Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.
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| http://dx.doi.org/10.3390/molecules24081552 | DOI Listing |
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Article Synopsis
- This study introduces a new high-performance liquid chromatography (HPLC) method with amperometric detection for accurately measuring silybin, a key component in nutricosmetics derived from Silybum marianum.
- It details a solid sample preparation technique using ultrasound-assisted extraction (UAE) to effectively isolate silybin before analyzing it chromatographically.
- The developed method achieves efficient separation of silybin A and B in under 20 minutes, demonstrating a low detection limit and high recovery rate, making it superior to previous methods for silybin analysis.
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