David R. Schmidt, MD, team physician for the San Antonio Spurs.
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Weakly Supervised Classification of Mohs Surgical Sections Using Artificial Intelligence.
Mod Pathol
November 2024
Department of Pathology, Research Institute for Medical Innovation and Oncode Institute, Radboud University Medical Center, Nijmegen, The Netherlands.
Basal cell carcinoma (BCC) is the most frequently diagnosed form of skin cancer, and its incidence continues to rise, particularly among older individuals. This trend puts a significant strain on health care systems, especially in terms of histopathologic diagnostics required for Mohs micrographic surgery (MMS), which is used to treat BCC in sensitive locations to minimize tissue loss. This study aims to address the challenges in BCC detection within MMS whole-slide images by developing and evaluating a deep learning model that bridges weakly supervised learning with interpretable segmentation-based methods through attention maps.
View Article and Find Full Text PDFElbow Arthroscopy: Pearls to Avoid Nerve Injuries.
Arthroscopy
August 2024
Mississippi Sports Medicine and Orthopaedic Center, Jackson, Mississippi, U.S.A.. Electronic address:
Article Synopsis
- * Surgeons should palpate the ulnar nerve and use fluid to create space in the joint before making incisions, which helps minimize risks to surrounding structures.
- * Maintaining a clear view of instruments and joint surfaces during the procedure, as well as exercising caution around the ulnar and radial nerves, is essential for safe execution of elbow arthroscopy.
The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence.
J Virol
September 2024
Department of Microbiology and Immunology, Louisiana State University Health Sciences, Shreveport, Louisiana, USA.
Science is humanity's best insurance against threats from nature, but it is a fragile enterprise that must be nourished and protected. The preponderance of scientific evidence indicates a natural origin for SARS-CoV-2. Yet, the theory that SARS-CoV-2 was engineered in and escaped from a lab dominates media attention, even in the absence of strong evidence.
View Article and Find Full Text PDFWell-being Through the Synergy of Community Engagement, Health Equity, and Advocacy.
Thorac Surg Clin
August 2024
Department of Surgery, Thoracic Surgery, Henry Ford Health, 2799 West Grand Boulevard, Detroit, MI 48202, USA. Electronic address:
Facets of well-being for cardiothoracic surgeons include interconnectivity, or a sense of belonging within a community, and social relatedness. Striving for health equity achieves a sense of belonging and meaning to one's work. In "Elevating Health Equity: The Synergy of Community Engagement and Advocacy," the imperative for mentorship and diversification within health care is expounded, establishing a multitiered blueprint for equity.
View Article and Find Full Text PDFVirus-specific T cell therapy to treat refractory viral infections in solid organ transplant recipients.
Am J Transplant
September 2024
Department of Medicine, Division of Hematology, Columbia University Irving Medical Center, New York, New York, USA; Columbia Center for Translational Immunology, New York, New York, USA. Electronic address:
Solid organ transplant recipients require ongoing immunosuppression to prevent acute rejection, which puts them at risk of opportunistic infections. Viral infections are particularly challenging to prevent and treat as many establish latency and thus cannot be eliminated, whereas targets for small molecule antiviral medications are limited. Resistance to antivirals and unacceptable toxicity also complicate treatment.
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