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Ovarian surface epithelial cancer (OSEC) are an entity in which, according to genomics and pathology data accumulated in the last couple of decades, several different nosological entities with distinct etiologies are aggregated. In ovarian cancer, surgery is the pivot of treatment, to which medical oncological treatment is added by recommendation in most cases. This is a single centre sample of 263 cases with OSEC operated from January 2014 until December 2021 with a 28-month period of follow-up, until 30th April 2024.
View Article and Find Full Text PDFOvarian surface epithelial cancer (OSEC) are an entity in which, according to genomics and pathology data accumulated in the last couple of decades, several different nosological entities with distinct etiologies are aggregated. In ovarian cancer, surgery is the pivot of treatment, to which medical oncological treatment is added by recommendation in most cases. Material and This is a single centre sample of 263 cases with OSEC operated from January 2014 until December 2021 with a 28-month period of follow-up, until 30th April 2024.
View Article and Find Full Text PDFB7-H3 promotes nasopharyngeal carcinoma progression by regulating CD8+ T cell exhaustion.
Immun Inflamm Dis
September 2024
The First Affiliated Hospital of Jinan University, Guangzhou, China.
Article Synopsis
- - The study investigates the role of B7-H3 protein in nasopharyngeal carcinoma (NPC) and how it affects tumor growth and immune response, particularly its interaction with the co-stimulatory receptor 4-1BB on CD8+ T cells.
- - Researchers used techniques like RNA knockdown and mouse models to demonstrate that reducing B7-H3 levels leads to increased apoptosis, slower tumor growth, and reduced migration of NPC cells, both in vitro and in vivo.
- - The results reveal that B7-H3 promotes tumor growth and immune evasion by interacting with 4-1BB, causing CD8+ T cell exhaustion, thereby highlighting its potential as a target for cancer therapy.
Generation, characterization, and toxicological assessment of reference ultrafine soot particles with different organic content for inhalation toxicological studies.
Sci Total Environ
November 2024
Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics (CMA), Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany; Joint Mass Spectrometry Center (JMSC) at Chair of Analytical Chemistry, Institute of Chemistry, University of Rostock, Albert-Einstein-Strasse 27, D-18059 Rostock, Germany.
Ultrafine particles (UFP) are the smallest atmospheric particulate matter linked to air pollution-related diseases. The extent to which UFP's physical and chemical properties contribute to its toxicity remains unclear. It is hypothesized that UFP act as carriers for chemicals that drive biological responses.
View Article and Find Full Text PDFDoes neoadjuvant chemotherapy reduce surgical complexity in patients with advanced-stage epithelial ovarian cancer?
BMC Womens Health
July 2024
Department of Gynecologic Oncology, Ankara Bilkent City Hospital, 06800, Ankara, Turkey.
Background: This study aimed to determine the effect of neoadjuvant chemotherapy (NACT) on the complex surgical procedures required in addition to staging surgery for the need to achieve a residual tumor 1 cm or less in a population of stage IIIC-IV epithelial ovarian cancer patients.
Methods: Patients were referred for NACT if preoperative imaging and/or intraoperative evaluation confirmed that it was not possible to achieve a residual tumor size of 1 cm or less with cytoreductive surgery or if the patient had a poor performance status and a high American Society of Anesthesiologists (ASA) score. Surgical complexity was defined as complex or non-complex.
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