Formaldehyde produced from d-ribose under neutral and alkaline conditions.

Toxicol Rep

State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing, 100101, China.

Published: April 2019

Formaldehyde is toxic and has been implicated in the pathologies of various diseases, such as cognitive impairment and cancer. Though d-ribose is widely studied and provided as a supplement to food such as flavor and drinks, no laboratories have reported that d-ribose is involved in the formaldehyde production. Here, we show that formaldehyde is produced from d-ribose in lysine or glycine solution and Tris-HCl buffer under neutral and alkaline conditions. Intraperitoneal injection of C57BL/6J mice with d-ribose significantly increased the concentration of brain formaldehyde, compared to the injection with d-glucose or saline. These data suggest that formaldehyde levels should be monitored for the people who take d-ribose as a supplement.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454226PMC
http://dx.doi.org/10.1016/j.toxrep.2019.02.005DOI Listing

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