AI Article Synopsis
- A protozoan parasite causes amebiasis, which results in significant health issues globally due to tissue destruction.
- Recent research has uncovered new mechanisms of tissue damage, such as trogocytosis, a parasite cytokine that fuels inflammation, and the parasitic manipulation of the host's immune response.
- Future research should aim at targeting these mechanisms to create better prevention and treatment strategies for amebiasis.
Article Abstract
Purpose Of Review: is a protozoan parasite that causes amebiasis, which remains a significant cause of morbidity and mortality worldwide. causes tissue destruction which leads to clinical disease. This review outlines some of the recent advances that have furthered our understanding of the processes that lead to the tissue damage caused by
Recent Findings: Recent studies have identified new mechanisms involved in -induced tissue damage. These include (i) new form of contact-dependent killing called trogocytosis; (ii) parasite-produced cytokine, macrophage migration inhibitory factor, that contributes to inflammation; (iii) exploitation of host immune response to promote invasion; and (iv) the contribution of the gut microbiome to clinical disease.
Summary: Targeting these mechanisms that result in tissue injury should be a focus of future research for the development of improved preventive and therapeutic strategies for amebiasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449278 | PMC |
| http://dx.doi.org/10.1007/s40588-019-0113-6 | DOI Listing |
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