AI Article Synopsis
- SF, or Maesaengi, is a green alga known for its unique taste and high chlorophyll content, offering antioxidant and health benefits.
- In a study involving mice with atopic dermatitis (AD), SF treatment significantly reduced AD symptoms, inflammation, and proinflammatory cytokine levels.
- SF also inhibited inflammatory responses in human skin cells (HaCaT keratinocytes) by suppressing cytokine production and altering key signaling pathways, indicating its potential as a therapeutic option for AD.
Article Abstract
(SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of body-induced atopic dermatitis (AD) and in tumor necrosis factor- and interferon--stimulated HaCaT keratinocytes. SF treatment (200 mg/mouse) inhibited the development of AD symptoms, compared to that in the control group, as evidenced from the improved dorsal skin lesion, reduced thickness and infiltration of inflammatory cells and smaller lymph nodes, and reduced levels of proinflammatory cytokines. In HaCaT keratinocytes, SF (10, 25, and 50 g/mL) suppressed the production of proinflammatory cytokines in a dose-dependent manner. In addition, SF reduced the phosphorylation of signal transducer and activator of transcription 1, which is one of the major signaling molecules involved in cellular inflammation. These results suggested that SF could be a potential therapeutic alternative for the treatment of AD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441517 | PMC |
| http://dx.doi.org/10.1155/2019/3760934 | DOI Listing |
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