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In vitro sensitivity of antimalarial drugs and correlation with clinico-parasitological response following treatment with a 3-day artesunate-mefloquine combination in patients with falciparum malaria along the Thai-Myanmar border.
Acta Trop
February 2017
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani 12121, Thailand. Electronic address:
A 3-day artesunate-mefloquine combination therapy has been using as first-line treatment for acute uncomplicated Plasmodium falciparum malaria in Thailand since 1995 on the background of mefloquine resistance. The aim of the present study was to assess sensitivity of P. falciparum isolates (n=44) in an area along the Thai-Myanmar border (year 2009) to artesunate, mefloquine, chloroquine and quinine, including their correlation with clinico-parasitological response.
View Article and Find Full Text PDFExploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis.
Evid Based Complement Alternat Med
May 2016
Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
The clinical efficacy and safety of Shiunko ointment (phase II clinical trial) was investigated in 40 Ethiopian patients with cutaneous leishmaniasis. Patients were randomized to receive treatment with Shiunko ointment or placebo (n = 20, each), applied on the lesion twice a day for 4 weeks. Clinicoparasitological assessments were performed before treatment, weekly for 4 weeks, and then 4, 8, and 12 weeks after the end of treatment.
View Article and Find Full Text PDFImplementation of revised strategy of filaria control-baseline clinico-parasitological survey.
J Commun Dis
June 2000
National Institute of Communicable Diseases, Varanasi Branch, Varanasi, U.P.
A clinico-epidemiological study of filariasis was carried out in Varanasi District in October and November, 1997 to generate baseline data for assessing the impact of Mass Drug Administration (MDA) in the district. Disease rate was found to be 6.6% (9.
View Article and Find Full Text PDFExaminations of 1599 residents of a polyinvasion focus at a seaside province Ha Nam Nin, Vietnam, have revealed clonorchiasis in approximately 13.9% of the examinees; in subjects aged over 30 this value was 29.3%.
View Article and Find Full Text PDFStudies on liver profile after prolonged praziquantel courses for schistosomiasis mansoni in Egyptian children on a field level.
J Egypt Soc Parasitol
December 1990
Department of Tropical Medicine, Faculty of Medicine, Al Azhar Univ., Egypt.
The effect of prolonged praziquantel courses on the clinical, sonographic and functional aspects of the liver in bilharzial and nonbilharzial school-children on village level was investigated in this study. Bilharzial--positive school--children were divided into three groups according to Praziquantel regimes. Each case received an initial dose of 40 mg/Kg.
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