AI Article Synopsis
- Developing sensitive MRI contrast agents is crucial for early disease detection, but traditional agents struggle due to high proton density in the body.
- Xe hyperCEST NMR/MRI offers a more selective alternative by detecting distinct chemical environments, enhancing specificity over conventional methods.
- The study introduces a new rotaxane-based Xe hyperCEST NMR contrast agent that activates in the presence of H₂O, allowing for detection of low micromolar levels of H₂O linked to disease states.
Article Abstract
The development of sensitive and chemically selective MRI contrast agents is imperative for the early detection and diagnosis of many diseases. Conventional responsive contrast agents used in H MRI are impaired by the high abundance of protons in the body. Xe hyperCEST NMR/MRI comprises a highly sensitive complement to traditional H MRI because of its ability to report specific chemical environments. To date, the scope of responsive Xe NMR contrast agents lacks breadth in the specific detection of small molecules, which are often important markers of disease. Herein, we report the synthesis and characterization of a rotaxane-based Xe hyperCEST NMR contrast agent that can be turned on in response to H O , which is upregulated in several disease states. Added H O was detected by Xe hyperCEST NMR spectroscopy in the low micromolar range, as well as H O produced by HEK 293T cells activated with tumor necrosis factor.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660407 | PMC |
| http://dx.doi.org/10.1002/anie.201903045 | DOI Listing |
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