Kurt Benirschke, noted pathologist and animal conservationist, passed away on September 10, 2018 at the age of 94. Kurt Benirschke is a legendary figure in perinatal pathology and was likely the first pathologist to have a genuine interest in the placenta. With Shirley Driscoll, he wrote the first textbook on placental pathology-The Pathology of the Human Placenta published in 1967. Dr Benirschke combined interests in both human and animal biology-not only was he a noted pathologist and geneticist, but he had expertise in the reproduction of humans and many mammalian species. During his career, he advanced comparative pathology of placentation, and due to his work on the preservation of endangered species, he likely saved a number of species from extinction. He also became internationally known for his creation of the "frozen zoo" collecting embryos and tissues of numerous endangered species. I have been privileged to be among his many friends and colleagues who were awed by the breadth of his extensive knowledge, his humility, and his sense of humor. Benirschke's life and career, which is reviewed here, should be an inspiration to the Pediatric and Developmental Pathology readership.
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http://dx.doi.org/10.1177/1093526619843723 | DOI Listing |
Placenta
September 2017
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA; Great Ape Trust/Bonobo Hope Sanctuary, Des Moines, IA, USA; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address:
Introduction: The placenta is arguably the most anatomically variable organ in mammals even though its primary function is conserved.
Method: Using RNA-Seq, we measured the expression profiles of 55 term placentas of 14 species of mammals representing all major eutherian superordinal clades and marsupials, and compared the evolution of expression across clades.
Results: We identified a set of 115 core genes which is expressed (FPKM ≥10) in all eutherian placentas, including genes with immune-modulating properties (ANXA2, ANXA1, S100A11, S100A10, and LGALS1), cell-cell interactions (LAMC1, LUM, and LGALS1), invasion (GRB2 and RALB) and syncytialization (ANXA5 and ANXA1).
Birth Defects Res A Clin Mol Teratol
February 2016
Department of Pathology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.
Background: A total of 75% of monozygotic twins share 1 monochorionic placenta where placental anastomoses cause several serious complications, for example, acardiac twinning. Acardiac twins lack cardiac function but grow by perfusion of arterial blood from the pump twin. This rare pregnancy has 50% natural pump twin mortality but accurate risk prediction is currently impossible.
View Article and Find Full Text PDFFetal Diagn Ther
September 2016
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, Calif., USA.
Monochorionic diamniotic twins share a single placenta and have intertwin vascular communications that link the circulatory systems of the twins together. Twin anemia-polycythemia sequence (TAPS) is an atypical form of twin-twin transfusion syndrome (TTTS) caused by net transfer of blood from one fetus to the other and is characterized by large intertwin hemoglobin differences in the absence of oligohydramnios and polyhydramnios. This condition may develop spontaneously (sTAPS) or as a result of residual vascular communications after prior laser surgery.
View Article and Find Full Text PDFAm J Med Genet A
August 2013
Division of Dysmorphology and Teratology, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093-0828, USA.
Gastroschisis is a congenital abdominal wall defect where there is herniation of abdominal organs. Optimal maternal nutritional intake, in particular, fatty acids, are vital for proper growth and development of the fetus. This pilot case-control study explored the association of several biomarkers of fatty acids and gastroschisis.
View Article and Find Full Text PDFSurg Pathol Clin
March 2013
Department of Pathology, UCSD Medical Center, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. Electronic address:
This article discusses pathologies found in monozygotic twinning. Detailed information is provided regarding the development during monozygotic twin formation: embryo development, twin-to-twin transfusion syndrome, acardiac twinning, vanishing twins, conjoined twins, and Beckwith-Weidmann syndrome twins. An algorithm describing the approach for identifying pathology in a placenta with multiple pregnancies is presented.
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