The antibacterial effect of the lactoperoxidase/thiocyanate/hydrogen peroxide system (lactoperoxidase system) was tested against strains of Campylobacter jejuni and Campylobacter coli isolated from poultry. The effect was studied at different pH-values and temperatures in UHT-milk (control); UHT-milk containing lactoperoxidase, sodiumthiocyanate and hydrogen peroxide (lactoperoxidase system); UHT-milk containing lactoperoxidase, sodiumthiocyanate, hydrogen peroxide and sodiumpyrosulfite (inactivated lactoperoxidase system). The lactoperoxidase system had a strong bactericidal effect against C. jejuni and C. coli . The bactericidal effect was more rapid at 37°C compared to 20°C. The effect of lactoperoxidase system decreased with decreasing pH-values. The fastest reduction in viable numbers was obtained at pH 6.6 and 37°C.
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http://dx.doi.org/10.4315/0362-028X-52.9.638 | DOI Listing |
Transl Cancer Res
November 2024
Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Background: Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy. The key problem lies in the complexity of the genome, so that drug resistance and relapse have become the main problems. Recent studies have found an association between synaptotagmin-like 4 (SYTL4) and drug resistance in triple-negative breast cancer and its high expression is correlated with poor prognosis; however, it is unclear whether this gene is associated with the prognosis of AML.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Kaiserstrasse 12, 76131 Karlsruhe, Germany. Electronic address:
J Clin Pediatr Dent
November 2024
Dental Research Center, Mashhad University of Medical Sciences, 0098051 Mashhad, Iran.
Dental caries is a complex condition that results from a combination of genetic and environmental factors. Several genes have been found to play a role in teeth development and have been associated with various dental traits. In this study, our objective was to examine the potential correlation between the ectodysplasin a receptor (EDAR)-associated death domain (EDARADD), Lactoperoxidase (LPO) and Actinin Alpha 2 (ACTN2) gene polymorphisms and susceptibility to dental caries.
View Article and Find Full Text PDFSci Rep
October 2024
Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Kaiserstrasse 12, Karlsruhe, 76131, Germany.
It is imperative to explore new biocompatible drugs with low toxicity for use in medicinal fields such as fighting tumors. Bovine lactoperoxidase (BLPO) stems from the most important enzymes in the bovine whey that provide a proper pattern for nano-formulation with nanomaterials. LPO is a suitable protein to be coated or adsorbed to alginate modified graphene oxide (GO-SA), which forms the modified GO-SA-LPO hybrid structure.
View Article and Find Full Text PDFInt Dent J
October 2024
Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, South Korea (ROK); Institute of Aging, Seoul National University, Seoul, South Korea (ROK). Electronic address:
Objective: This study aimed to investigate the effects of zinc compounds on the candidacidal activities of lysozyme and the peroxidase (PO) and glucose oxidase-mediated peroxidase (GO-PO) systems against Candida albicans.
Methods: Four zinc compounds were used: zinc chloride, gluconate, lactate, and sulphate. Three antimicrobial systems were used: hen egg-white lysozyme (HEWL), the PO system [bovine lactoperoxidase (bLPO), potassium thiocyanate, and hydrogen peroxide], and the GO-PO system (bLPO, potassium thiocyanate, glucose oxidase, and glucose).
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