AI Article Synopsis
- * Out of 53 ART-naive participants, 11.3% were found to have transmitted drug resistance (TDR), which is categorized as moderate according to World Health Organization (WHO) guidelines.
- * The main findings included 8.3% of RT sequences showing surveillance drug resistance mutations to non-nucleoside reverse transcriptase inhibitors (NNRTI), while no significant DRMs were detected for protease or nucleoside reverse transcriptase inhibitors (NRTIs).
Article Abstract
A cross-sectional study was undertaken to examine the prevalence and pattern of HIV drug resistance mutations (DRMs) among recently HIV-1-infected and antiretroviral therapy (ART)-naive individuals from Chennai, South India. The HIV-1 pol gene encompassing the protease and reverse transcriptase (RT) regions were analyzed from 53 ART-naive HIV-1-infected individuals using an in-house method for identifying DRMs by genotyping. The overall prevalence of transmitted drug resistance (TDR) was found to be 11.3% (6/53), which is categorized as moderate level (5.0%-15.0%) of TDR according to the World Health Organization (WHO) survey guidelines. Surveillance drug resistance mutations to non-nucleoside reverse transcriptase inhibitors (NNRTI) were observed in 8.3% ( = 4) of the 48 RT sequences analyzed. No major DRMs related to the protease and nucleoside reverse transcriptase inhibitor (NRTIs) class of drugs were identified.
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| http://dx.doi.org/10.1089/AID.2019.0022 | DOI Listing |
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