The rise in human longevity is one of humanity's crowning achievements. Although advances in public health beginning in the 19th century initiated the rise in life expectancy, recent gains have been achieved by reducing death rates at middle and older ages. A debate about the future course of life expectancy has been ongoing for the last quarter century. Some suggest that historical trends in longevity will continue and radical life extension is either visible on the near horizon or it has already arrived; whereas others suggest there are biologically based limits to duration of life, and those limits are being approached now. In "inconvenient truths about human longevity" we lay out the line of reasoning and evidence for why there are limits to human longevity; why predictions of radical life extension are unlikely to be forthcoming; why health extension should supplant life extension as the primary goal of medicine and public health; and why promoting advances in aging biology may allow humanity to break through biological barriers that influence both life span and health span, allowing for a welcome extension of the period of healthy life, a compression of morbidity, but only a marginal further increase in life expectancy.
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http://dx.doi.org/10.1093/gerona/glz098 | DOI Listing |
Sci Total Environ
January 2025
Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, 310030, Hangzhou, China. Electronic address:
Thanks to the progress of science and technology, human life expectancy has dramatically increased in the past few decades, but accompanied by rapid ageing of population, resulting in increased burden on society. At the same time, the living environment, especially the electromagnetic environment, has also greatly changed due to science and technology advances. The effect of artificial electromagnetic fields (EMFs) emitted from power lines, mobile phones, wireless equipment, and other devices on ageing and ageing-related diseases are receiving increasing attention.
View Article and Find Full Text PDFCureus
December 2024
Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad, IND.
Background Toothbrush manufacturers commonly use bristle materials such as nylon, polybutylene terephthalate, polypropylene, polyethylene terephthalate, boar hair, bamboo, carbon fiber, silicone, polylactic acid, or their modifications such as Curen. Nylon filaments have long been demonstrated to be durable and are widely used, but not much is known regarding the performance of Curen filaments compared to nylon filaments. This in vitro study compared the stiffness, abrasion potential, abrasion resistance, and bristle surface changes of Curen and nylon filaments.
View Article and Find Full Text PDFJ Intellect Dev Disabil
March 2024
University of Sydney, Camperdown, Australia.
Background: There is little research comparatively assessing prevalence of pain between older people either with or without intellectual disability. This paper explores health and social factors associated with chronic pain in these two groups.
Method: A cross-sectional survey was undertaken in New South Wales and Queensland, Australia.
Am J Physiol Endocrinol Metab
January 2025
Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA.
Exogenous glucose oxidation is reduced 55% during aerobic exercise after three days of complete starvation. Whether energy deficits more commonly experienced by athletes and military personnel similarly affect exogenous glucose oxidation and what impact this has on physical performance remains undetermined. This randomized, longitudinal parallel study aimed to assess the effects of varying magnitudes of energy deficit (DEF) on exogenous glucoseoxidation and physical performance compared to energy balance (BAL).
View Article and Find Full Text PDFJ Infect Dis
January 2025
Department of Internal Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Background: In people with HIV (PWH) who are virally suppressed (VS) on antiretroviral therapy (ART), abdominal obesity (AO) is linked to neurocognitive impairment (NCI), potentially due to visceral adiposity, inflammation, and reduced insulin-like growth factor 1 (IGF-1). Tesamorelin, a growth hormone-releasing hormone, reduces AO and increases IGF-1, suggesting it might mitigate NCI in VS PWH.
Methods: This 6-month, Phase II randomized, open-label clinical trial compared Tesamorelin versus standard-of-care (SOC) for NCI in abdominally obese PWH.
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