Context-specific tumor suppression by PHF6.

Blood

The Jackson Laboratory.

Published: April 2019

In this issue of , McRae et al report that loss of plant homeodomain finger 6 () increases the ability of hematopoietic stem and progenitor cells (HSPCs) to sustain long-term engraftment and can specifically synergize with the oncogenic homeobox transcription factor TLX3 to cause lymphoid neoplasms.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022434PMC
http://dx.doi.org/10.1182/blood-2019-03-900829DOI Listing

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