Microglia Sculpt Sex Differences in Social Behavior. | LitMetric

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Microglia Sculpt Sex Differences in Social Behavior. | LitMetric

Microglia Sculpt Sex Differences in Social Behavior.

Caroline J Smith Staci D Bilbo

Neuron

Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA 02114, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

Published: April 2019

- Microglia play a crucial role in shaping neural circuits during brain development.
- A study by VanRyzin et al. (2019) reveals that endocannabinoids signal microglia to engulf new astrocytes in a specific brain area of male rats.
- This process influences the differences in social play behavior observed between sexes.

Microglia are increasingly recognized as developmental sculptors of neural circuits. In this issue of Neuron, VanRyzin et al. (2019) demonstrate a novel mechanism by which endocannabinoids drive microglia to phagocytose newborn astrocytes in the medial amygdala of male rats, promoting sex differences in social play behavior.

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http://dx.doi.org/10.1016/j.neuron.2019.03.039	DOI Listing

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