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Quantitative analysis of choroidal vascular structures and anatomical changes in pachychoroid spectrum diseases using ultra-widefield SS-OCTA.
Sci Rep
January 2025
The Department of Ophthalmology, General Hospital of Central Theater Command, No. 627 Wuluo Road, Wuchang District, Wuhan, 430000, Hubei, China.
This study used ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA) to analyze and compare choroidal blood flow and anatomical changes in eyes affected by central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV), and uncomplicated pachychoroid (UCP). The findings revealed distribution patterns of vortex veins across the three patient groups and provided initial findings insights into the origin of choroidal neovascularization (CNV) in PNV. A total of 44 patients with CSC, 38 with PNV, and 46 with UCP were included in the analysis.
View Article and Find Full Text PDFMachine Learning Quantification of Fluid Volume in Eyes With Retinal Vein Occlusion Treated With Aflibercept: The REVOLT Study.
J Vitreoretin Dis
December 2024
Octane Imaging Lab, Toronto, ON, Canada.
Article Synopsis
- The study examined how ischemia, retinal fluid, and layer thickness impact visual acuity (VA) in patients with retinal vein occlusion (RVO) using swept-source optical coherence tomography (OCT).
- Patients received aflibercept injections and were monitored through OCT analysis at baseline and after 3 and 6 months, correlating OCT findings with changes in best-corrected VA (BCVA).
- Results showed that a combination of intraretinal fluid (IRF) volume, thickness measurements in specific retinal layers, and ischemic indices had the strongest correlation with changes in VA, highlighting useful clinical markers for RVO management.
FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age related macular degeneration.
Eur J Pharmacol
December 2024
Center of Clinical Research, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China. Electronic address:
Purpose: Age-related macular degeneration (AMD) is the leading cause of vision loss among the elderly individuals. Retinal pigment epithelium (RPE) ferroptosis is a significant pathogenetic component in AMD. This study aims to elucidate the role and mechanisms of fatty acid desaturase 1 (FADS1) in ferroptosis as well as AMD progression.
View Article and Find Full Text PDFThe protective role of gamma zone peripapillary atrophy in diabetic retinopathy: insights from deep learning and SS-OCT angiography.
Front Cell Dev Biol
December 2024
Department of Ophthalmology, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
Article Synopsis
- The study investigates the connection between peripapillary atrophy (PPA) and diabetic retinopathy (DR) in patients with type 2 diabetes using advanced imaging techniques.
- Participants were categorized based on PPA types and evaluated for DR severity, revealing that specific features of PPA, particularly the gamma zone, may correlate with lower DR grades.
- The findings suggest that the gamma zone PPA might indicate resilience against DR through potential changes in the eye's structure due to conditions like myopia.
Retinal Neurovascular Impairment in Full-Course Diabetic Retinopathy: The Guangdong Diabetic Retinopathy Multiple-Omics Study.
Invest Ophthalmol Vis Sci
December 2024
Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Purpose: The purpose of this study was to explore the succession of the central and peripheral neurovascular and microstructural impairments in patients with full-course diabetic retinopathy (DR), consisting of preclinical DR, nonproliferative DR (NPDR), and proliferative DR (PDR).
Methods: Our analysis included 81 participants (including 23 healthy controls, 23 with preclinical DR [diabetes without retinopathy], 13 with NPDR, and 22 with PDR) from the Guangdong Diabetic Retinopathy Multiple Omics Study. Retinal structure and function were evaluated and quantified using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA), electroretinography (ERG), and adaptive optics scanning laser ophthalmoscopy (AOSLO).
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