Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well- known risk factor of atherosclerotic vascular diseases which are common comorbidities in psoriasis. The aim of this study was to evaluate serum Lp-PLA2 level in psoriatic patients and elucidate possible associations with disease activity, metabolic or inflammatory parameters and systemic treatment. We enrolled 33 patients with active plaque-type psoriasis and 11 healthy controls. Blood samples were collected before and after 3 months of systemic treatment with acitretin or methotrexate. Serum Lp-PLA2 level were evaluated by enzyme-linked immunosorbent assay. Serum Lp-PLA2 level in patients with psoriasis did not statistically differ comparing to the control group ( = .2). However, in patients with severe psoriasis Lp-PLA2 was significantly higher than in the controls before and after treatment ( = .03, = .01, respectively). The lipase did not correlate with BMI ( = .22); however, a statistical significance was noted between psoriatics with obesity compared to the controls ( = .03). No significant effect of systemic treatment combined ( = .5) nor separately with acitretin ( = .5) or methotrexate ( = .1) on the Lp-PLA2 level was found, despite clinical improvement. Lp-PLA2 assay might be helpful in assessment of the risk of cardiometabolic comorbidities development especially in patients with severe psoriasis and obesity.
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