AI Article Synopsis
- The study looked at how ferritin and vitamin D levels relate to fasting glucose and diabetes in older men (aged 70-89) living in Western Australia.
- The researchers found that while ferritin levels were linked to higher fasting glucose, they did not correlate with the presence of diabetes.
- In contrast, higher levels of vitamin D were associated with lower fasting glucose and a reduced risk of diabetes, highlighting the potential importance of vitamin D in diabetes prevention among older adults.
Article Abstract
Aims: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.
Methods: Cross-sectional analysis of 4153 community-dwelling men aged 70 to 89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D, and glucose were assayed. Diabetes was ascertained from self-report, medications, and fasting glucose.
Results: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1 SD increase in ferritin, P = .006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1 SD, P < .001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, P = .83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR = 0.57, 95% CI = 0.43-0.75, P < .001). There was no interaction between ferritin and vitamin D on diabetes risk.
Conclusions: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions, which raise vitamin D concentrations, would reduce incidence of diabetes in this expanding demographic group.
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| http://dx.doi.org/10.1002/dmrr.3172 | DOI Listing |
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