AI Article Synopsis
- The study presents a method for synthesizing F-difluoromethylarenes using three components: a boron reagent, ethyl bromofluoroacetate, and a specific type of fluoride.
- Two main reactions are highlighted in the process: a copper-catalyzed cross-coupling reaction and a manganese-mediated fluorodecarboxylation.
- These steps are crucial for efficiently producing the desired fluorinated compounds in the lab.
Article Abstract
Herein, we report the radiosynthesis of F-difluoromethylarenes the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated F-fluorodecarboxylation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429591 | PMC |
| http://dx.doi.org/10.1039/c8sc05096a | DOI Listing |
Publication Analysis
Top Keywords
ethyl bromofluoroacetate
8
synthesis f-difluoromethylarenes
4
f-difluoromethylarenes aryl
4
aryl boronic
4
boronic acids
4
acids ethyl
4
bromofluoroacetate [f]fluoride
4
[f]fluoride report
4
report radiosynthesis
4
radiosynthesis f-difluoromethylarenes
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!