Covalent inhibitors of GAPDH characterized by a 3-bromoisoxazoline warhead were developed, and their mode of interaction with the target enzyme was interpreted by means of molecular modeling studies: some of them displayed a submicromolar antiplasmodial activity against both chloroquine sensitive and resistant strains of , with good selectivity indices.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466836 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.8b00592 | DOI Listing |
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