Natural sounds have rich spectrotemporal dynamics. Spectral information is spatially represented in the auditory cortex (ACX) via large-scale maps. However, the representation of temporal information, e.g., sound offset, is unclear. We perform multiscale imaging of neuronal and thalamic activity evoked by sound onset and offset in awake mouse ACX. ACX areas differed in onset responses (On-Rs) and offset responses (Off-Rs). Most excitatory L2/3 neurons show either On-Rs or Off-Rs, and ACX areas are characterized by differing fractions of On and Off-R neurons. Somatostatin and parvalbumin interneurons show distinct temporal dynamics, potentially amplifying Off-Rs. Functional network analysis shows that ACX areas contain distinct parallel onset and offset networks. Thalamic (MGB) terminals show either On-Rs or Off-Rs, indicating a thalamic origin of On and Off-R pathways. Thus, ACX areas spatially represent temporal features, and this representation is created by spatial convergence and co-activation of distinct MGB inputs and is refined by specific intracortical connectivity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238664 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2019.03.069 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neural correlates of perceptual plasticity in the auditory midbrain and thalamus.
J Neurosci
January 2025
Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland, 20742.
Hearing is an active process in which listeners must detect and identify sounds, segregate and discriminate stimulus features, and extract their behavioral relevance. Adaptive changes in sound detection can emerge rapidly, during sudden shifts in acoustic or environmental context, or more slowly as a result of practice. Although we know that context- and learning-dependent changes in the sensitivity of auditory cortical (ACX) neurons support many aspects of perceptual plasticity, the contribution of subcortical auditory regions to this process is less understood.
View Article and Find Full Text PDFDevelopmental encoding of natural sounds in the mouse auditory cortex.
Cereb Cortex
November 2024
Department of Life Sciences and Systems Biology (DBIOS), University of Turin, via Accademia Albertina 13, 10123 Turin, Italy.
Mice communicate through high-frequency ultrasonic vocalizations, which are crucial for social interactions such as courtship and aggression. Although ultrasonic vocalization representation has been found in adult brain areas along the auditory pathway, including the auditory cortex, no evidence is available on the neuronal representation of ultrasonic vocalizations early in life. Using in vivo two-photon calcium imaging, we analyzed auditory cortex layer 2/3 neuronal responses to USVs, pure tones (4 to 90 kHz), and high-frequency modulated sweeps from postnatal day 12 (P12) to P21.
View Article and Find Full Text PDFFirst report of causing leaf rot on in China.
Plant Dis
June 2024
Nanyang Normal University, Nanyang, China;
Article Synopsis
- Artemisia argyi, a medicinal herb from East Asia, faced a severe leaf rot outbreak in Henan Province, China, during May to July 2023, impacting about 200 acres with a 65% incidence rate.
- The disease initially presented as pale yellow spots on the leaves, which progressed to yellowish-brown lesions, ultimately causing complete leaf wilting.
- Researchers collected diseased leaf samples, isolated strains of the fungi Fusarium and Alternaria, and confirmed the presence of Fusarium verticillioides through morphological and genetic testing.
Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex.
Proc Natl Acad Sci U S A
July 2023
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205.
Coordinated functioning of the two cortical hemispheres is crucial for perception. The human auditory cortex (ACx) shows functional lateralization with the left hemisphere specialized for processing speech, whereas the right analyzes spectral content. In mice, virgin females demonstrate a left-hemisphere response bias to pup vocalizations that strengthens with motherhood.
View Article and Find Full Text PDFThe Anterior Cingulate Cortex Promotes Long-Term Auditory Cortical Responses through an Indirect Pathway via the Rhinal Cortex in Mice.
J Neurosci
June 2023
Department of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, 0000, P.R. China
Sensory cortical areas are robustly modulated by higher-order cortices. Our previous study shows that the anterior cingulate cortex (ACC) can immediately and transiently enhance responses in the mouse auditory cortex (ACx). Here, we further examined whether strong activation of ACC neurons can induce long-term effects in mice of both sexes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!