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Dupilumab-associated ocular surface disease in atopic dermatitis patients: Clinical characteristics, ophthalmic treatment response and conjunctival goblet cell analysis.
Allergy
August 2023
Department of Dermatology and Allergology, National Expertise Center for Atopic Dermatitis, University Medical Center Utrecht, Utrecht, the Netherlands.
Background: Dupilumab-associated ocular surface disease (DAOSD) is frequently reported as side effect in atopic dermatitis (AD) patients. Therefore, the aim of this study was to investigate the frequency and severity of DAOSD, ophthalmic treatment response and to learn more about the effect of dupilumab on conjunctival goblet cells (GC).
Methods: This prospective study included dupilumab-treated AD patients between February 2020 and June 2022 from the University Medical Centre Utrecht.
Dermatology-ophthalmology collaborations are needed in dupilumab-associated ocular events.
J Am Acad Dermatol
June 2021
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:
Facial and neck erythema associated with dupilumab treatment: A systematic review.
J Am Acad Dermatol
May 2021
Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, Ontario, Canada. Electronic address:
Background: Neither dupilumab-associated facial erythema nor neck erythema was reported in phase 3 clinical trials for the treatment of atopic dermatitis, but there have been a number of reports of patients developing this adverse event in clinical practice.
Objective: To outline all cases of reported dupilumab-associated facial or neck erythema to better characterize this adverse event, and identify potential etiologies and management strategies.
Methods: A search was conducted on EMBASE and PubMed databases.
Learning About Dupilumab-Associated Conjunctivitis.
JAMA Dermatol
June 2019
University of Arizona Department of Medicine, Division of Dermatology, Tucson.
Learning About Dupilumab-Associated Conjunctivitis-Reply.
JAMA Dermatol
June 2019
Department of Dermatology, Feinberg School of Medicine, Northwestern, University, Chicago, Illinois.
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