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Molecular docking and analysis of the pharmacokinetics, toxicological profile and differential gene expression of bioactive compounds from .
Toxicol Rep
December 2024
Laboratory of Environmental Mutagenesis, Department of Biophysics and Biometry, IBRAG/UERJ (University of the State of Rio de Janeiro), 87 - Fundos, 4th floor, Vila Isabel, Rio de Janeiro, RJ 20551-030, Brazil.
Article Synopsis
- The study focuses on a genus of plants known for their therapeutic properties, particularly for treating conditions like tuberculosis and urinary infections, with an emphasis on a species endemic to Brazil.
- It identifies and analyzes the main compounds in its aqueous extract, finding Arbutin, Caffeic acid 4-O-glucoside, and Dihydroformononetin to be the most abundant; the gastrointestinal absorption and ability to cross the blood-brain barrier of these compounds were evaluated.
- The research indicates that Arbutin and Dihydroformononetin may lead to drug synthesis and shows potential for phytotherapeutic use, although some mutagenicity predictions require cautious interpretation.
Critical analysis of Echinacea preparations marketed in Germany.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Article Synopsis
- - Colds lead to significant work incapacity in 2023, impacting the German economy, with Echinacea products being popular as immune boosters and gaining attention during the COVID-19 pandemic.
- - A study examined 22 Echinacea herbal preparations, highlighting inconsistencies in their ingredients and formulations, despite their similar market presentation.
- - To better match clinical research with real-world products, new studies should analyze the actual compositions of these preparations and consider factors like dosage and work incapacity as outcomes.
Nitric Oxide and Small and Intermediate Calcium-Activated Potassium Channels Mediate the Vasodilation Induced by Apigenin in the Resistance Vessels of Hypertensive Rats.
Molecules
November 2024
Laboratory of Cardiometabolic Pharmacology, Postgraduate Program in Pharmacology (UFPR), Federal University of Paraná, Curitiba 81531-980, PR, Brazil.
Article Synopsis
- Apigenin, a flavonoid thought to benefit cardiovascular health, was studied for its effects on vascular function in Spontaneously Hypertensive Rats (SHRs) to understand its mechanisms of action.
- Vascular beds from SHRs were tested with varying doses of apigenin, showing that its ability to lower blood pressure depended on the presence of endothelial cells and was significantly reduced by inhibitors of nitric oxide and potassium channels.
- The research concluded that apigenin causes vasodilation primarily through endothelial nitric oxide and calcium-activated potassium channels, suggesting its potential for therapeutic use in cardiovascular diseases and the need for more clinical studies.
Effects of DC on an Innovative Animal Model of Cardiometabolic Syndrome.
Pharmaceutics
November 2024
Laboratory of Cardiometabolic Pharmacology, Federal University of Paraná (UFPR), Curitiba 81531-990, Brazil.
Cardiometabolic syndrome (CMS) is a complex clinical condition that encompasses metabolic dysregulation, cardiovascular disease, and diabetes risk factors. Worldwide, CMS is underdiagnosed, and its occurrence significantly increases cardiovascular morbimortality. Despite available pharmacological treatments, the approach is fragmented, and the associated clinical conditions are treated independently.
View Article and Find Full Text PDFAnalysis of Adverse Reactions Associated with the Use of -Containing Herbal Products.
Pharmaceuticals (Basel)
November 2024
Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH 's-Hertogenbosch, The Netherlands.
Products from various parts of species are traditionally applied as a cardiotonic. In Europe and the USA, mainly Jacq. (Lindm.
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