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Impaired Exercise Capacity in High-Risk Diabetic Cardiomyopathy: The ARISE-HF Cardiopulmonary Exercise Testing Subanalysis.
Circ Heart Fail
January 2025
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (Y.L., J.L.J., G.D.L.).
Background: Objective indices of functional capacity in patients with diabetic cardiomyopathy and stage B heart failure (HF) have not been comprehensively defined. We sought to characterize the cardiopulmonary exercise characteristics of individuals with diabetic cardiomyopathy at high risk for overt HF.
Methods: The relationships from cardiopulmonary exercise testing with clinical and laboratory characteristics of participants with diabetic cardiomyopathy were evaluated using baseline data from the ARISE-HF trial (Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure).
Long COVID-19-related and non-COVID-19 postviral olfactory dysfunction a comparative MRI study focusing on the olfactory cleft and bulbs.
Front Neurol
January 2025
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Objective: To compare the magnetic resonance imaging (MRI) features of the olfactory cleft (OC) and olfactory bulbs (OBs) in patients with long COVID-19-related (LCOD) and non-COVID-19 postviral olfactory dysfunction (NCPVOD) to explore mechanisms underlying persistent olfactory dysfunction.
Methods: This retrospective analysis included patients diagnosed with LCOD or NCPVOD at the China-Japan Friendship Hospital between February 2023 and July 2024. All patients underwent olfactory psychophysical testing (Sniffin' Sticks), a visual analogue scale (VAS) for olfactory function, and high-resolution MRI scans of the olfactory pathway.
Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse.
Front Cell Dev Biol
January 2025
Mechanobiology Laboratory, Nagoya University Graduate School of Medicine, Nagoya, Japan.
The high interstitial ATP concentration in the cancer microenvironment is a major source of adenosine, which acts as a strong immune suppressor. However, the source of ATP release has not been elucidated. We measured ATP release during hypotonic stress using a real-time ATP luminescence imaging system in breast cell lines and in primary cultured mammary cells.
View Article and Find Full Text PDFPurpose: Primary anterior cruciate ligament (ACL) reconstruction graft failure remains a significant health concern in young patients. Despite the high incidence of poor graft integration in these patients and the resulting high failure rate, little consideration has been given to the quality of the bone into which the graft is anchored at reconstruction. Therefore, we investigated post ACL injury mineralized tissue changes in the ACL femoral entheses of young males and compared them to changes previously reported for young females.
View Article and Find Full Text PDFLow-Cost Modification to Enhance Bone Marrow Aspiration Efficiency: A Technical Report.
Cureus
December 2024
Anesthesiology, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Bone marrow aspiration is an essential procedure for diagnosing hematological conditions and therapeutic applications, such as bone marrow aspirate concentrate (BMAC) therapy for non-union of bones. This report presents a case of a 35-year-old male with femoral non-union treated with BMAC, requiring the collection of a large bone marrow aspirate volume. A novel, low-cost modification to the standard bone marrow aspiration apparatus was developed using components from an intravenous (IV) drip set, including a rubber bulb connector and a luer lock connector.
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