BRCA1-No Matter How You Splice It.

(breast cancer 1, early onset), a well-known breast cancer susceptibility gene, is a highly alternatively spliced gene. alternative splicing may serve as an alternative regulatory mechanism for the inactivation of the gene in both hereditary and sporadic breast cancers, and other -associated cancers. The alternative transcripts of can mimic known functions, possess unique functions compared with the full-length transcript, and in some cases, appear to function in opposition to full-length In this review, we will summarize the functional "naturally occurring" alternative splicing transcripts of and then discuss the latest next-generation sequencing-based detection methods and techniques to detect alternative splicing patterns and their potential use in cancer diagnosis, prognosis, and therapy.