AI Article Synopsis
- The immune system has a complex role in cancer, providing protection while also potentially aiding tumor progression through changes in immunogenicity and the tumor microenvironment.
- Recent research highlights the functions of innate lymphoid cells (ILCs) in cancer, revealing their diverse roles and impact on tumor behavior.
- Understanding ILCs' involvement in cancer, especially within the context of cancer immunoediting, is crucial for developing effective treatment strategies.
Article Abstract
The immune system plays a dual role in cancer. It conveys protective immunity but also facilitates malignant progression, either by sculpting tumor immunogenicity or by creating a microenvironment that can stimulate tumor outgrowth or aid in a subsequent metastatic cascade. Innate lymphoid cells (ILCs) embody this functional heterogeneity, although the nature of their responses in cancer has only recently begun to be unveiled. We provide an overview of recent insights into the role of ILCs in cancer. We also discuss how ILCs fit into the conceptual framework of cancer immunoediting, which integrates the dual role of the immune system in carcinogenesis. A broader understanding of their relevance in cancer is essential towards the design of successful therapeutic strategies.
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| http://dx.doi.org/10.1016/j.it.2019.03.004 | DOI Listing |
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