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Optimizing Management of Febrile Young Infants Without Serum Procalcitonin.
Pediatrics
January 2025
Departments of Pediatrics and Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC.
Background: Febrile young infants are at risk of invasive bacterial infections (IBIs; bacteremia or bacterial meningitis). American Academy of Pediatrics (AAP) guidelines recommend that when procalcitonin testing is unavailable, C-reactive protein (CRP), absolute neutrophil count (ANC) and temperature should be used to identify low-risk infants. We sought to determine the optimal combination of these inflammatory markers to predict IBI when procalcitonin is unavailable.
View Article and Find Full Text PDFNeutrophil-to-Lymphocyte Ratio Differentiates Infections from Sterile Inflammation in First Week of Acute Pancreatitis.
Dig Dis Sci
January 2025
Department of Gastroenterology, Christian Medical College, Vellore, Tamil Nadu, India.
Background: Differentiating infections from sterile inflammation is crucial in early AP management.
Aim: This study aimed to assess the capability of Neutrophil-to-Lymphocyte Ratio (NLR) and procalcitonin to differentiate between sterile inflammation and infections in the first week of AP and to analyze the source, microbiological profile, and impact of infections in AP.
Methods: Consecutive patients presenting within 5 days of symptom onset were included.
Characteristics of patients with non-severe infections of different SARS-CoV-2 omicron subvariants in China.
Front Med (Lausanne)
December 2024
Hebei Key Laboratory of Immune Mechanism of Major Infectious Diseases and New Technology of Diagnosis and Treatment, The Fifth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Objective: The aim of this study was to explore the clinical characteristics of patients infected with different Omicron subvariants presenting non-severe disease, evaluate the safety and efficacy of Azvudine for treatment of COVID-19, in order to broaden understanding of Omicron subvariant infections.
Method: A total of 244 individuals with Omicron subvariant (BA.2.
A Narrative Review of the Role of Blood Biomarkers in the Risk Prediction of Cardiovascular Diseases.
Cureus
December 2024
Public Health Sciences, Scientific Knowledge for Ageing and Neurological Ailments (SKAN) Research Trust, Bengaluru, IND.
Article Synopsis
- Cardiovascular disease (CVD) is a major global health issue, making it essential to find biomarkers that can detect it early in healthy people to enhance preventive measures and improve overall health outcomes.
- Various biomarkers, such as atherogenic lipoproteins and inflammatory markers like C-reactive protein (CRP), have shown connections to CVD risk factors, aiding in risk prediction when combined with traditional indicators.
- Emerging biomarkers like myeloperoxidase (MPO) and procalcitonin (PCT) are being explored for their potential in early detection of systemic infections, emphasizing the importance of identifying the best biomarker combinations for effective diagnosis and risk assessment.
Associations between health, productive performance and oral fluid biomarkers in commercial pig farms.
Porcine Health Manag
December 2024
Pig Development Department, Animal and Grassland Research and Innovation Centre, Teagasc Moorepark, P61C996, Fermoy, Co. Cork, Ireland.
Background: Oral fluid contains analytes that may be reflective of health and welfare in pig herds. Additionally, oral fluid collection is a more convenient and cost-effective option when compared to blood sampling, increasing the potential of oral fluid as a non-invasive alternative tool. While a growing number of biomarkers can be measured in porcine oral fluid, the use of these analytes to compare commercial herds in veterinary practice is still limited.
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