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Decoding the Nexus: Cellular and Molecular Mechanisms Linking Stroke and Neurotoxic Microenvironments in Brain Cancer Patients.
Biomolecules
November 2024
Global Health Neurology Lab, Sydney, NSW 2150, Australia.
Stroke is an often underrecognized albeit significant complication in patients with brain cancer, arising from the intricate interplay between cancer biology and cerebrovascular health. This review delves into the multifactorial pathophysiological framework linking brain cancer to elevated stroke risk, with particular emphasis on the crucial role of the neurotoxic microenvironment (NTME). The NTME, characterized by oxidative stress, neuroinflammation, and blood-brain barrier (BBB) disruption, creates a milieu that promotes and sustains vascular and neuronal injury.
View Article and Find Full Text PDFNAION AND ANTICOAGULANTS: BRIDGING THE GAP WITH RATIONALE-BASED THERAPY.
J Ayub Med Coll Abbottabad
November 2024
Cataract and Refractive Surgery Division, Ophthalmology Department, Faculty of Medicine University of Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta-Indonesia.
Article Synopsis
- The study investigates the effects of anticoagulant therapy on vascular and visual function in patients with NAION, a complex eye disorder.
- Both hypercoagulable and non-hypercoagulable groups received daily aspirin, with the hypercoagulable group also receiving warfarin.
- Results showed that patients in the hypercoagulation group had significant visual field improvements, suggesting that anticoagulant therapy could help slow down disease progression and improve clinical outcomes.
Venous thromboembolism is a multifactorial dis ease and major cause of morbidity and mortality. Absolute risk of venous thromboembolism is less than 1 per 10,000 per year in women of reproductive age. Hormonal contraception is a common risk situation for venous thromboembolism in this part of the population.
View Article and Find Full Text PDFAssessment of Genetic Variants Linked to Susceptibility to Mechanical Prosthetic Valve Thrombosis.
Am J Cardiol
January 2025
Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital, Istanbul, Türkiye; Division of Health Sciences, Ardahan University, Ardahan, Türkiye.
Prosthetic valve thrombosis (PVT) is a critical and life-threatening condition driven by multifactorial etiologies, including genetic predispositions. The study was designed as a single-center retrospective manner. Echocardiographic features and genetic test including factor II/prothrombin (G20210A), factor V Leiden (G1691A), factor V R2 (A4070G), apolipoprotein (Apo) B-100 (G10708A), ApoE (C112R), ApoE (R158C), methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, factor XIII G103T (V34L), β-fibrinogen (455G>A), PAI-1 4G/5G, and HPA-1 GPIIIa (T196C) genotyping variations were assessed.
View Article and Find Full Text PDFPolymorphism of Folate Metabolism Genes among Ethnic Kazakh Women with Preeclampsia in Kazakhstan: A Descriptive Study.
Biology (Basel)
August 2024
Department of Obstetrics and Gynecology #2, West-Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Kazakhstan.
Introduction: Preeclampsia is a severe multifactorial complication of pregnancy. Studies found associations between folate metabolism genes' polymorphisms and preeclampsia. However, investigations in this field are limited among Asian populations.
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