The problem of the reliable estimation of astronauts' radiation exposure doses in deep space is very important and relevant in connection with the accepted space research programmes. The effective dose value based on ICRP Publication 103 presents too conservative an estimate of an astronaut's radiation risk. A more realistic dose can be calculated on the basis of relationships between the radiation quality factor and linear energy transfer or linear energy or Z*/β , according to the NASA concept. In addition, it is reasonable to use a set of tissue weighting coefficients (normalised relative detriments) that have been averaged over a cohort of working age males similar to the male astronaut cohort. The closest to the male astronauts is the NASA cohort of males aged 30-60 years who have never smoked. The fluence-to-effective dose equivalent conversion coefficients calculated specially for male astronauts are compared. Different approaches to radiation risk estimation for astronauts are discussed.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1088/1361-6498/ab0583 | DOI Listing |
BMC Biol
January 2025
Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, Beijing, China.
Background: Human responses and acclimation to the environmental stresses of high altitude and low oxygen are multifaceted and regulated by multiple genes. However, the mechanism of how the body adjusts in a low-oxygen environment is not yet clear.
Results: Hence, we performed RNA sequencing (RNA-seq) and ATAC sequencing (ATAC-seq) to observe the changes of transcriptome and chromatin accessibility in the peripheral blood of eight individuals at 1 h post adaptation in a simulated plateau environment with 3500 m and 4500 m altitude, respectively.
Sci Rep
January 2025
College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Parkinson's disease (PD), as the second most prevalent neurodegenerative disorder worldwide, impacts the quality of life for over 12 million patients. This study aims to enhance the accuracy of early diagnosis of PD through non-invasive methods, with the goal of enabling earlier intervention in the disease process. To this end, we constructed an open-field environment using flexible sensors under dark conditions, conducting experiments on a mouse model of Parkinson's disease alongside a normal control group.
View Article and Find Full Text PDFFASEB J
January 2025
National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Microgravity-induced cardiac remodeling and dysfunction present significant challenges to long-term spaceflight, highlighting the urgent need to elucidate the underlying molecular mechanisms and develop precise countermeasures. Previous studies have outlined the important role of miRNAs in cardiovascular disease progression, with miR-199a-3p playing a crucial role in myocardial injury repair and the maintenance of cardiac function. However, the specific role and expression pattern of miR-199a-3p in microgravity-induced cardiac remodeling remain unclear.
View Article and Find Full Text PDFSci Rep
January 2025
Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, 153-8904, Japan.
Given the increasing urban population and frenetic mobility, understanding how individuals perceive crowding at large-scale events is crucial for effective crowd management and safety. This study focuses on Tokyo Big Sight in Japan exhibitions to examine participants' perceptions of peak crowding times, locations, and local density, and compare them with the actual measurements. Our methodology integrated questionnaires with beacon tag data.
View Article and Find Full Text PDFNutrients
December 2024
State Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Background: Long-term fasting demonstrates greater therapeutic potential and broader application prospects in extreme environments than intermittent fasting.
Method: This pilot study of 10-day complete fasting (CF), with a small sample size of 13 volunteers, aimed to investigate the time-series impacts on gut microbiome, serum metabolome, and their interrelationships with biochemical indices.
Results: The results show CF significantly affected gut microbiota diversity, composition, and interspecies interactions, characterized by an expansion of the Proteobacteria phylum (about six-fold) and a decrease in Bacteroidetes (about 50%) and Firmicutes (about 34%) populations.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!