AI Article Synopsis
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), poses a long-standing global health threat, particularly in China where multidrug-resistant TB (MDR-TB) is a rising issue due to genetic mutations in the bacteria that lead to drug resistance.* -
- A study conducted on 270 Mtb isolates from Yunnan, China, between 2014-2016 utilized spoligotyping to identify various genotypes, revealing a significant prevalence of Beijing genotypes among MDR strains.* -
- The findings indicate that 102 out of 270 isolates were drug-resistant, with 52 classified as MDR, highlighting the urgent need for improved diagnostic and treatment strategies, and contributing to the understanding of M
Article Abstract
Tuberculosis (TB) is an infectious disease caused by (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb. Increasing cases of multidrug-resistant (MDR) tuberculosis (MDR-TB) is a serious public health problem to TB control in China. Spontaneous mutations in the Mtb genome can alter proteins which are the target of drugs, making the bacteria drug resistant. The purpose of the present study was to analyze the genotype of Mtb isolates from some areas in Yunnan, China and explore the association between genotypes and MDR-TB. Using spoligotyping, we identified Beijing genotypes, six non-Beijing genotypes and a number of orphan genotypes from 270 Mtb isolates from patients in Yunnan Province during 2014-2016. Of 270 Mtb isolates, 102 clinical Mtb strains were identified as drug-resistant (DR) by drug susceptibility testing (DST), among them, 52 MDR strains. Beijing genotypes occupied the highest MDR proportion (78.85%) followed by the orphan genotypes (15.38%). The characteristics of MDR strains showed high genetic diversity. The results will help to efficiently improve diagnosis and treatment and provide valuable information for Mtb molecular epidemiology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542976 | PMC |
| http://dx.doi.org/10.1042/BSR20181746 | DOI Listing |
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