AI Article Synopsis
- Multiple myeloma (MM) is a disease that can't be cured right now, and its causes involve complex genetics.
- Long non-coding RNAs (lncRNAs) are important molecules that help with many body processes but how they affect MM is not fully understood.
- Researchers are studying how these lncRNAs work to better understand their roles and find new ways to fight against MM.
Article Abstract
Multiple myeloma (MM) is still an incurable disease, and its pathogenesis involves cytogenetics and epigenetics. In recent years, the roles of long non-coding RNAs (lncRNAs) in MM have been deeply studied by scholars. LncRNAs are defined as a class of non-protein-coding transcripts greater than 200 nucleotides in length, which are involved in a large spectrum of biological processes, including proliferation, differentiation, apoptosis, invasion, and chromatin remodeling. However, little is known about the specific mechanisms of these lncRNAs. They can act as oncogenic and/or tumor-suppressive factors in the development and progression of MM. But that how do they work remains unclear. In this review, the recent progress in the study of functional lncRNAs associated with MM was summarized and the present knowledge about their expression and roles was discussed, to provide guidance for the in-depth functional study of lncRNAs.
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| http://dx.doi.org/10.1111/ejh.13237 | DOI Listing |
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