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Effect of depressive symptoms on health services utilization in the HIV and hepatitis C co-infected population in Canada.
AIDS Care
December 2024
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.
Depression is common among people living with HCV and HIV, which contributes to health services utilization (HSU). It is unknown whether successful HCV treatment affects this. We examined depressive symptoms and HSU in people co-infected with HIV-HCV and their association with sustained virologic response (SVR) during the direct-acting antiviral era.
View Article and Find Full Text PDFMetabolomic Changes Associated With the Change in HVPG After DAAs Therapy in HCV Cirrhotic Patients.
Liver Int
January 2025
Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Background And Aims: In response to direct-acting antivirals (DAAs) therapy, patients who experience a decrease in hepatic venous pressure gradient (HVPG) considerably reduce liver complications and have increased survival. This study aimed to assess the metabolomic changes associated with the changes in HVPG from the start of DAA therapy until 48 weeks after effective DAA therapy in patients with advanced HCV-related cirrhosis.
Methods: We carried out a multicenter longitudinal study in 31 patients with advanced hepatitis C virus (HCV)-related cirrhosis.
Generation of Optimized Consensus Sequences for Hepatitis C virus (HCV) Envelope 2 Glycoprotein (E2) by a Modified Algorithm: Implication for a Pan-genomic HCV Vaccine.
Avicenna J Med Biotechnol
January 2024
Department of Molecular Virology, Pasteur Institute of Iran, Tehran, Iran.
Article Synopsis
- - The development of a vaccine for Hepatitis C Virus (HCV) is essential despite the effectiveness of existing treatments, particularly focusing on inducing Pangenomic neutralizing Antibodies (PnAbs) against the diverse HCV Envelope 2 protein.
- - Current algorithms for creating Consensus Sequences (CS) face challenges such as rigidity and insensitivity to evolutionary changes, prompting researchers to modify the "Majority" algorithm with BLOSUM matrices and assess it against the "Fitness" algorithm.
- - The "Fitness" algorithm outperformed others by producing well-defined HCVE2 sequences for all HCV genotypes, considering evolutionary factors and offering improved properties for vaccine development, suggesting its applicability for other variable pathogens as well. *
Different dynamics of soluble inflammatory mediators after clearance of respiratory SARS-CoV-2 versus blood-borne hepatitis C virus infections.
Sci Rep
November 2024
Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH) OE 6810, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Viral infections can be acute or chronic, with the immune system pivotal in immunopathogenesis. The potential reversibility of inflammation post-viral elimination is of current interest. This study compares the dynamics of soluble inflammatory mediators (SIM) during and after respiratory infections with SARS-CoV-2 and blood-borne acute and chronic hepatitis C virus (HCV) infections.
View Article and Find Full Text PDFExternalized nurse-led model for hepatitis C virus microelimination and impact of drug use profile.
Gastroenterol Hepatol
November 2024
Liver Unit, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain. Electronic address:
Background And Objective: Direct-acting antivirals have greatly simplified the treatment of hepatitis C virus (HCV), yet circuits that bring diagnosis and treatment closer to people who inject drugs (PWID) are needed to achieve the elimination targets of the WHO. With this purpose we have established an externalized nurse-driven circuit among former and active PWID in an addiction centre (AC) and a harm reduction centre (HRC).
Methods And Settings: The nursing staff offered HCV screening, diagnosis and treatment to the AC and HRC users, administered medication after the hepatologist's remote prescription to those with an active infection who accepted being treated, and implemented educational and harm reduction interventions.
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