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| http://dx.doi.org/10.3389/fpls.2019.00347 | DOI Listing |
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A recent study by Wang , published in the , provided preventative and therapeutic strategies for the comorbidity of obesity and depression. The gutbrain axis, which acts as a two-way communication system between the gastrointestinal tract and the central nervous system, plays a pivotal role in the pathogenesis of these conditions. Evidence suggests that metabolic byproducts, such as short-chain fatty acids, lipopolysaccharide and bile acids, which are generated by the gut microbiota, along with neurotransmitters and inflammatory mediators within the gut-brain axis, modulate the host's metabolic processes, neuronal regulation, and immune responses through diverse mechanisms.
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