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| http://dx.doi.org/10.4103/ijps.IJPS_165_18 | DOI Listing |
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Cannabichromene as a Novel Inhibitor of Th2 Cytokine and JAK/STAT Pathway Activation in Atopic Dermatitis Models.
Int J Mol Sci
December 2024
Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul #222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Cannabichromene (CBC) is one of the main cannabinoids found in the cannabis plant, and although less well known than tetrahydrocannabinol (THC) and cannabidiol (CBD), it is gaining attention for its potential therapeutic benefits. To date, CBC's known mechanisms of action include anti-inflammatory, analgesic, antidepressant, antimicrobial, neuroprotective, and anti-acne effects through TRP channel activation and the inhibition of inflammatory pathways, suggesting that it may have therapeutic potential in the treatment of inflammatory skin diseases, such as atopic dermatitis (AD), but its exact mechanism of action remains unclear. Therefore, in this study, we investigated the effects of CBC on Th2 cytokines along with the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in AD pathogenesis.
View Article and Find Full Text PDFModulation of Pain Sensitivity by Ascl1- and Lhx6-Dependent GABAergic Neuronal Function in Streptozotocin-Diabetic Mice.
Mol Ther
December 2024
Gachon Pain Center and Department of Physiology, Gachon University College of Medicine, Incheon, Republic of Korea. Electronic address:
Painful diabetic neuropathy commonly affects the peripheral nervous system in individuals with diabetes. However, the pathological processes and mechanisms underlying diabetic neuropathic pain remain unclear. We aimed to identify the overall profiles and screen for genes potentially involved in pain mechanisms using transcriptome analysis of the dorsal root ganglion of diabetic mice treated with streptozotocin (STZ).
View Article and Find Full Text PDFAnalysis of oxytocin and oxytocin receptor expressions after hand therapy treatment in a mouse model of chemotherapy-induced peripheral neuropathy .
Neuro Endocrinol Lett
December 2024
Department of Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.
Objectives: We aimed to investigate the effect of hand therapy (HT) on oxytocin and oxytocin receptor expression in a chemotherapy-induced peripheral neuropathy (CIPN) model mouse.
Methods: CIPN model mouse was induced by intraperitoneal injection of paclitaxel (PTX; 4 mg/kg) on days 0, 2, 4 and 6 of the study. HT was performed on the CIPN mice once daily for 14 consecutive days, starting on day 8 after the PTX injection.
Intracisternal AAV9-MAG- Vector Reverses Motor Deficits in Adult Adrenomyeloneuropathy Mice.
Hum Gene Ther
December 2024
Laboratoire des Maladies Neurodégénératives, MIRCen Institute, Fontenay-aux-Roses, France.
Worldwide, thousands of male patients who carry ATP Binding Cassette Subfamily D Member 1 () mutations develop adrenomyeloneuropathy (AMN) in mid-adulthood, a debilitating axonopathy of the spinal cord. Today AAV gene therapy brings the most hope for this orphan disease. We previously reported that an AAV9-MAG- vector injected intravenously in the neonatal period prevented the disease in 2-year-old mice, the AMN mouse model.
View Article and Find Full Text PDFEffectiveness of reverse first dorsal metatarsal artery flap for reconstruction of distal foot in electrical injuries.
Burns
November 2024
Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Introduction: The severity of electrical injuries depends on the voltage, the duration of exposure to current, and the trajectory of the current through the body. The reconstruction for defects caused by electric current is a difficult process.
Objective: The purpose of this study is to investigate the effectiveness of the reverse first dorsal metatarsal artery (FDMA) flap in the reconstruction of distal foot injuries caused by electric currents.
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