The purpose of this study was to compare patients who were diagnosed with hyperemesis gravidarum (HG) with the control group by identifying anxiety, depression, sleep disorder levels and the relationship between them. This study involved 98 first-trimester pregnant women (46 HG patients and 52 control group patients) who applied to the Hitit University Medicine Faculty Obstetrics and Gynecology clinic. Statistically significant differences were found between HG patients and the control group according to the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores ( < .001 and < .001, respectively). In addition, a significant relationship was found between the classification performed according to the Pittsburgh Sleep Quality Index (PSQI) scores and HG ( < .001). According to PSQI scores, while 60.9% of HG patients had severe sleep disorders, 7.7% of the patients in the control group had severe sleep disorders. These findings clearly show that the PSQI scores increased as a result of nausea and vomiting. Impact statement The aetiology of hyperemesis gravidarum has not yet been clarified. There are some studies that relate pregnancy to anxiety and depression. In our study, we aimed to evaluate first-trimester vomiting with psychological disorders. There was a statistically significant relationship between PSQI scores and BAI and BDI scores in the HG group. However, this relationship was not detected in the control group. Also, PSQI scores increased as a result of nausea and vomiting in HG cases.
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http://dx.doi.org/10.1080/01443615.2019.1572725 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Institute of Science and Technology Austria, AT-3400 Klosterneuburg, Austria.
Biophysical constraints limit the specificity with which transcription factors (TFs) can target regulatory DNA. While individual nontarget binding events may be low affinity, the sheer number of such interactions could present a challenge for gene regulation by degrading its precision or possibly leading to an erroneous induction state. Chromatin can prevent nontarget binding by rendering DNA physically inaccessible to TFs, at the cost of energy-consuming remodeling orchestrated by pioneer factors (PFs).
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Cell Biology, Duke University Medical Center, Durham, NC 27701.
In species with genetic sex determination (GSD), the sex identity of the soma determines germ cell fate. For example, in mice, XY germ cells that enter an ovary differentiate as oogonia, whereas XX germ cells that enter a testis initiate differentiation as spermatogonia. However, numerous species lack a GSD system and instead display temperature-dependent sex determination (TSD).
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Division of Livestock Infectious Diseases, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Historically considered to be nonenveloped, hepatitis E virus (HEV), an important zoonotic pathogen, has recently been discovered to egress from infected cells as quasi-enveloped virions. These quasi-enveloped virions circulating in the blood are resistant to neutralizing antibodies, thereby facilitating the stealthy spread of infection. Despite abundant evidence of the essential role of the HEV-encoded ORF3 protein in quasi-enveloped virus formation, the underlying mechanism remains unclear.
View Article and Find Full Text PDFJ Neurosurg
January 2025
1Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui.
Objective: Endovascular treatment (EVT) is an effective treatment for patients with acute vertebrobasilar artery complex occlusion (VBAO). However, the benefit of bridging thrombolysis prior to EVT remains controversial. The purpose of the present study is to explore the best treatment strategy between bridging treatment (BT) and direct EVT in patients with acute VBAO.
View Article and Find Full Text PDFJ Occup Environ Med
January 2025
Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center location Vrije Universiteit, Amsterdam, the Netherlands.
Objective: To evaluate the process of an online cognitive rehabilitation program aimed at supporting cancer survivors experiencing cognitive problems at work.
Methods: Cancer survivors (n = 279) were randomized to one of the intervention groups (i.e.
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