AI Article Synopsis
- Ions typically cross cell membranes through carrier or channel mechanisms, but a new class of transporters called molecular swings has been developed, utilizing an innovative swing mechanism for efficient ion transport.
- These molecular swings feature a 15-crown-5 unit that binds and transports ions, demonstrating exceptionally high transport activities with effective concentrations (EC values) of 46 nm for potassium and 110 nm for sodium ions.
- Notably, these transport activities remain effective even in environments rich in cholesterol, with elevated EC values of 130 nm for potassium and 326 nm for sodium ions.
Article Abstract
Ions are transported across membrane mostly via carrier or channel mechanisms. Herein, a unique class of molecular-machine-inspired membrane transporters, termed molecular swings is reported that utilize a previously unexplored swing mechanism for promoting ion transport in a highly efficient manner. In particular, the molecular swing, which carries a 15-crown-5 unit as the ion-binding and transporting unit, exhibits extremely high ion-transport activities with EC values of 46 nm (a channel:lipid molar ratio of 1:4800 or 0.021 mol % relative to lipid) and 110 nm for K and Na ions, respectively. Remarkably, such ion transport activities remain high in a cholesterol-rich environment, with EC values of 130 (0.045 mol % relative to lipid/cholesterol) and 326 nm for K and Na ions, respectively.
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| http://dx.doi.org/10.1002/anie.201901833 | DOI Listing |
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