The Limitations of Using Cognitive Cutoff Scores for Enrollment in Alzheimer Trials.

Am J Geriatr Psychiatry

Geriatric Psychiatry Research Program (REP, KH, LM, DGH, BPF); Department of Psychiatry (REP, DGH, BPF), Harvard Medical School, Boston.

Published: October 2019

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jagp.2019.02.014DOI Listing

Publication Analysis

Top Keywords

limitations cognitive
4
cognitive cutoff
4
cutoff scores
4
scores enrollment
4
enrollment alzheimer
4
alzheimer trials
4
limitations
1
cutoff
1
scores
1
enrollment
1

Similar Publications

Estimating self-performance when making complex decisions.

Sci Rep

January 2025

Centre for Brain, Mind and Markets, Faculty of Business and Economics, The University of Melbourne, Melbourne, Australia.

Metacognition, the ability to monitor and reflect on our own mental states, enables us to assess our performance at different levels - from confidence in individual decisions to overall self-performance estimates (SPEs). It plays a particularly important part in computationally complex decisions that require a high level of cognitive resources, as the allocation of such limited resources presumably is based on metacognitive evaluations. However, little is known about metacognition in complex decisions, in particular, how people construct SPEs.

View Article and Find Full Text PDF

Functional magnetic resonance imaging (fMRI) has dramatically advanced non-invasive human brain mapping and decoding. Functional near-infrared spectroscopy (fNIRS) and high-density diffuse optical tomography (HD-DOT) non-invasively measure blood oxygen fluctuations related to brain activity, like fMRI, at the brain surface, using more-lightweight equipment that circumvents ergonomic and logistical limitations of fMRI. HD-DOT grids have smaller inter-optode spacing (~ 13 mm) than sparse fNIRS (~ 30 mm) and therefore provide higher image quality, with spatial resolution ~ 1/2 that of fMRI, when using the several source-detector distances (13-40 mm) afforded by the HD-DOT grid.

View Article and Find Full Text PDF

Exercise capacity and the psychosocial effect in preterm born infants - Should we do more?

Paediatr Respir Rev

January 2025

Department of Respiratory Medicine, The Children's Hospital at Westmead, Westmead, Sydney, New South Wales 2145, Australia; Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Camperdown, Sydney, New South Wales 2006, Australia.

Physical activity is crucial for children's physical, cognitive, and social development, reducing the risk of non-communicable diseases and improving overall well-being. A major legacy of extremely preterm delivery is respiratory limitation with reduced lung function and decreased exercise capacity which can be further exacerbated by inactivity and deconditioning. Strategies to increase incidental physical activities in early childhood and participation in sport and more formal exercise programmes in middle childhood have the potential to optimize cardiopulmonary function, improve quality of life, and foster social interactions in childhood and beyond, thereby providing benefits that extend far beyond the physical domain.

View Article and Find Full Text PDF

Determinants of dementia diagnosis in U.S. primary care in the past decade: A scoping review.

J Prev Alzheimers Dis

February 2025

Department of Health Behavior and Health Equity, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029, United States.

Background: Alzheimer's disease and related dementias (ADRD) are chronically underdiagnosed in the U.S., particularly among minoritized racial and ethnic groups.

View Article and Find Full Text PDF

Development of a Patient Reported Outcome Measure of Side Effects for Patients Taking Calcineurin Inhibitors: The FACIT-CNI-Ntx.

Am J Kidney Dis

January 2025

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, USA; Northwestern University Transplant Outcomes Research Collaborative, Comprehensive Transplant Center, Feinberg School of Medicine, Chicago, IL, USA; Centre for Patient Reported Outcomes Research, Department of Applied Health Sciences, University of Birmingham, Edgbaston, Birmingham, UK.

Rationale & Objective: Valid measures of side effects are important to inform clinical use of calcineurin inhibitors (CNIs). This study sought to develop and establish the content validity of a PRO measure to capture side effects among kidney transplant recipients taking CNIs.

Study Design: Qualitative interviews for concept elicitation and cognitive debriefing.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!