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Importance of infarct topography in determination of stroke mechanism and recurrence risk: a post-hoc analysis of the dabigatran acute treatment of stroke trial.
BMJ Open
January 2025
School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia
Objective: To evaluate the relationship between infarct pattern, inferred stroke mechanism and risk of recurrence in patients with ischaemic stroke. The question is clinically relevant to optimise secondary stroke prevention investigations and treatment.
Design: We conducted a retrospective analysis of the dabigatran treatment of acute stroke II (DATAS II) trial (ClinicalTrials.
Renal vessel pseudoaneurysm as a cause of recurrent haematuria.
BMJ Case Rep
January 2025
Urology, Ranchi Urology Centre, Ranchi, Jharkhand, India.
Pseudoaneurysm is a common vascular abnormality marked by arterial wall disruption, with complications that can arise unpredictably and carry high morbidity and mortality rates. This case study emphasises the management of recurrent haematuria and clot retention in a young man presenting to the emergency department. It underscores the importance of early recognition and management of recurrent haematuria and clot retention caused by pseudoaneurysm, emphasising the critical role of multidisciplinary collaboration in optimising patient outcomes.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
Background: Connectome-based models of disease propagation are used to probe mechanisms of pathology spread in neurodegenerative disease. We present our network spreading model toolbox that allows the user to compare model fits across different models and parameters. We apply the toolbox to assess whether local amyloid levels affect production of pathological tau.
View Article and Find Full Text PDFBackground: Screening and disease monitoring are two core challenges of disease management in Alzheimer's Disease (AD). Digital speech and language features have shown promise as clinical outcomes in related disorders.
Methods: We reviewed how speech digital markers are currently used in AD, focusing on how behaviours are connected to underlying disease pathology.
Background: Recent developments in blood biomarkers (BBM) have shown promising results in diagnosing amyloid pathology in Alzheimer's Disease (AD). However, information on how these BBMs can best be used in clinical settings to optimise clinical decision-making and long-term health outcomes for individuals with AD is still lacking. We aim to assess the potential clinical and economic value of BBM in AD diagnosis within the context of disease-modifying treatment (DMT).
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