AI Article Synopsis
- - Dermatomyositis (DM) is an inflammatory muscle disease that causes muscle weakness and skin rashes, often linked to cancer.
- - Patients with DM who have specific autoantibodies called TIF1γ are at a higher risk of developing malignancies.
- - A case study of a 65-year-old woman showed that after her non-functional pancreatic tumor was surgically removed, her symptoms improved and her TIF1γ levels decreased.
Article Abstract
Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by proximal muscle weakness associated with a distinct cutaneous eruption. The association of DM with malignancy has been extensively described in the literature. Patients with DM that also have transcriptional intermediary factor 1γ (TIF1γ) autoantibodies (anti-p155, anti-p155/140) have higher rates of malignancy when compared to those without the autoantibody. We report the case of a 65-year-old woman with TIF1γautoantibody positive dermatomyositis associated with a non-functional pancreatic neuroendocrine tumor (PNET). Surgical resection of the PNET resulted in significant clinical improvement and a reduction of TIF1γ autoantibody levels in our patient.
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