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Sofosbuvir Polymorphs Distinguished by Linearly and Circularly Polarized Raman Microscopy.
Anal Chem
December 2024
Institute of Organic Chemistry and Biochemistry of the Academy of Sciences, Flemingovo Nám. 2, Prague 16610, Czech Republic.
Most currently marketed pharmaceuticals are manufactured in the solid state, where the bioavailability of the active pharmaceutical ingredient (API) can be optimized through different polymorphs, cocrystals, solvates, or salts. Efficient techniques are needed to monitor the structure of pharmaceuticals during production. Here, we explore the potential of linearly and circularly polarized Raman microscopy for distinguishing three polymorphs of sofosbuvir, an antiviral drug used to treat hepatitis C.
View Article and Find Full Text PDFAdaptation and validation of the Adolescent Psychotic-like Symptom Screener (APSS-6) in Spain: evidence from adult population.
BMC Psychol
November 2024
Department of Psychology, Universidad de Córdoba, Córdoba, Spain.
Background: Psychotic-like experiences are common in the general population and an important indicator of psychological vulnerability. One of the used instruments for their assessment is the Adolescent Psychotic-Like Symptom Screener (APSS). However, there are few studies on the APSS psychometric characteristics in different cultural contexts.
View Article and Find Full Text PDFPrecision of Radiation Chemistry Networks: Playing Jenga with Kinetic Models for Liquid-Phase Electron Microscopy.
Precis Chem
December 2023
Helmholtz Institute Erlangen-Nürnberg for Renewable Energy (IEK-11), Forschungszentrum Jülich GmbH, Cauerstr. 1, 91058 Erlangen, Germany.
Liquid-phase transmission electron microscopy (LP-TEM) is a powerful tool to gain unique insights into dynamics at the nanoscale. The electron probe, however, can induce significant beam effects that often alter observed phenomena such as radiolysis of the aqueous phase. The magnitude of beam-induced radiolysis can be assessed by means of radiation chemistry simulations potentially enabling quantitative application of LP-TEM.
View Article and Find Full Text PDFDynamic pharyngeal carriage of Neisseria species in healthy population.
Infect Genet Evol
November 2024
Hubei Key Laboratory of Edible Wild Plants Conservation & Utilization, Hubei Engineering Research Center of Characteristic Wild Vegetable Breeding and Comprehensive Utilization Technology, Hubei Normal University, Huangshi City, Hubei Province, PR China. Electronic address:
Considering the significant role of commensal Neisseria carried in the pharynx on the variation of N.meningitidis and the acquisition of its resistance genes, understanding the true Neisseria population colonizing the human pharynx is of great significance. In this study, we carried out a five-month continuous survey of oropharyngeal carriage in a certain healthy population to reveal the long-term carriage status of different Neisseria species.
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