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Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development.
Nat Commun
December 2024
Department of Homeostatic Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However, physiological roles and mechanisms of cell competition in vertebrates remain unclear. In addition, universal mechanisms regulating diverse cell competition are unknown.
View Article and Find Full Text PDFAssessing mechanical agency during apical apoptotic cell extrusion.
iScience
November 2024
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Homeostasis is necessary for epithelia to maintain barrier function and prevent the accumulation of defective cells. Unfit, excess, and dying cells in the larval zebrafish tail fin epidermis are removed via controlled cell death and extrusion. Extrusion coincides with oscillations of cell area, both in the extruding cell and its neighbors.
View Article and Find Full Text PDFNL101 synergizes with the BCL-2 inhibitor venetoclax through PI3K-dependent suppression of c-Myc in acute myeloid leukaemia.
J Transl Med
September 2024
Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
Background: Acute myeloid leukaemia (AML) comprises a group of heterogeneous and aggressive haematological malignancies with unsatisfactory prognoses and limited treatment options. Treatments targeting B-cell lymphoma-2 (BCL-2) with venetoclax have been approved for patients with AML, and venetoclax-based drug combinations are becoming the standard of care for older patients unfit for intensive chemotherapy. However, the therapeutic duration of either single or combination strategies is limited, and the development of resistance seems inevitable.
View Article and Find Full Text PDFExperimental Investigation of Regenerated Cellulose Microdialysis Probe Sterilization.
J Appl Polym Sci
June 2024
Department of Mechanical Engineering, UT Austin.
Sterilization of devices is important in hospitals, operating theatres, and emergency rooms. Microdialysis allows in vivo sampling of small molecules and is used for clinical studies. Microdialysis probes are made of soft, flexible, porous polymeric membranes.
View Article and Find Full Text PDFEliminating malaria vectors with precision-guided sterile males.
Proc Natl Acad Sci U S A
July 2024
School of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093.
Controlling the principal African malaria vector, the mosquito , is considered essential to curtail malaria transmission. However, existing vector control technologies rely on insecticides, which are becoming increasingly ineffective. Sterile insect technique (SIT) is a powerful suppression approach that has successfully eradicated a number of insect pests, yet the toolkit lacks the requisite technologies for its implementation.
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